A new study shows that omega 3 fatty acids protect from advanced prostate cancer. The study showed that men who carry the COX 2 gene variant that increases susceptibility to prostate cancer, gained significant protection against advanced prostate cancer compared to men with the lowest intake of omega 3 fatty acids
The study, published in Clinical Cancer Research, showed that men who consumed the highest amount of omega-3 fatty acids had a 63 percent risk reduction of aggressive prostate cancer when compared to men with the lowest amount of long chain omega-3 fatty acids.
John S. Witte, Ph.D., professor of epidemiology and biostatistics at the University of California San Francisco says Omega 3 fatty acids are known to protect against prostate cancer, and the current research …”is one of the first studies to show protection against advanced prostate cancer and interaction with COX-2.”
Men who possessed a variation of the COX 2 gene, rs4647310, were assessed to measure the effect of omega 3 fatty acids on prostate cancer. The COX 2 gene variant is known to produce inflammation that can lead to prostate cancer. When the men were given omega 3 fatty acids, the risk of advanced prostate cancer decreased substantially, but otherwise was five times higher.
"The COX-2 increased risk of disease was essentially reversed by increasing omega-3 fatty acid intake by a half a gram per day," said Witte. "If you want to think of the overall inverse association in terms of fish, where omega-3 fatty acids are commonly derived, the strongest effect was seen from eating dark fish such as salmon one or more times per week."
The study showed that omega 3 fatty acids, commonly derived from fish oils, protect against advanced prostate cancer in men at high risk, by reducing the inflammatory effect of the COX 2 gene variant that increases susceptibility to prostate cancer.
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